While the Desert Inn has since been replaced by other establishments, its legacy as home to one of the biggest slot jackpots remains.A Retiree’s DreamĪ 60-year-old woman, a resident of Las Vegas, invested approximately $300 and left with a whopping $34.9 million, making it the biggest Megabucks jackpot at that time. Incidentally, you can check out NoDepositDaily for more information on the biggest and best no deposit bonuses. The Desert Inn in Las Vegas is a symbol of the old Vegas charm, and in 2000, it made headlines for an unforgettable reason. Over the years, Megabucks has produced several multi-millionaire winners, making it one of the most sought-after slots in Vegas.Megabucks, powered by IGT, is a progressive slot machine, meaning every play on every machine in its network adds to the jackpot.This win still holds the record for the largest slot machine jackpot ever won. Investing $100, he hit the life-changing jackpot of $39.7 million. On March 21, 2003, a 25-year-old software engineer from Los Angeles decided to try his luck. Slot machines have changed the lives of many, but none quite as dramatically as the Megabucks machines at the Excalibur Casino in Las Vegas.